Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease
Identifieur interne : 000080 ( France/Analysis ); précédent : 000079; suivant : 000081Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease
Auteurs : T. Celeste Napier [États-Unis] ; Jean-Christophe Corvol [France] ; Anthony A. Grace [États-Unis] ; Jamie D. Roitman [États-Unis] ; James Rowe [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; Antonio P. Strafella [Canada]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.
Url:
DOI: 10.1002/mds.26068
PubMed: 25476402
PubMed Central: 4318759
Affiliations:
- Canada, France, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Illinois, Ontario, Pennsylvanie, Île-de-France
- Cambridge, Paris, Pittsburgh, Toronto
- Université de Cambridge, Université de Pittsburgh, Université de Toronto
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PMC:4318759Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P2">Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.</p>
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