La maladie de Parkinson au Canada (serveur d'exploration)

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Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

Identifieur interne : 000080 ( France/Analysis ); précédent : 000079; suivant : 000081

Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

Auteurs : T. Celeste Napier [États-Unis] ; Jean-Christophe Corvol [France] ; Anthony A. Grace [États-Unis] ; Jamie D. Roitman [États-Unis] ; James Rowe [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; Antonio P. Strafella [Canada]

Source :

RBID : PMC:4318759

Abstract

Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.


Url:
DOI: 10.1002/mds.26068
PubMed: 25476402
PubMed Central: 4318759


Affiliations:


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PMC:4318759

Le document en format XML

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